NUCANA PLC
3 Lochside Way
Edinburgh, EH12 9DT
United Kingdom
October 18, 2018
VIA EDGAR
U.S. Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
Attention: Ms. Irene Paik
| Re: | NuCana plc |
| Registration Statement on Form F-3 |
| Filed October 1, 2018 |
| File No. 333-227624 (the “Registration Statement”) |
| Acceleration Request |
Ladies and Gentlemen:
In accordance with Rule 461 of the Rules and Regulations promulgated under the Securities Act of 1933, as amended, NuCana plc (the “Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Monday, October 22, 2018, at 12:00 p.m., Eastern Time, or as soon as thereafter practicable.
The cooperation of the staff in meeting the timetable described above is very much appreciated.
Please contact John T. Rudy of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (617) 348-3050 with any questions regarding this request.
| Very truly yours, |
| NUCANA PLC |
| /s/ Donald Munoz |
| Donald Munoz Chief Financial Officer |
| cc: | Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. |
| John T. Rudy, Esq. |