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Our corporate headquarters are located at NuCana plc, 3 Lochside Way, Edinburgh EH12 9DT and our U.S. headquarters are located at NuCana Inc, 275 Grove Street, Suite 2-400 Newton, MA 02466.

The Company was founded in 1997 and commenced operations in 2008.

NuCana plc is incorporated under the laws of England and Wales (registered number 03308778).

NuCana plc completed the IPO of its American Depositary Shares (ADSs) on October 2, 2017 at a price of $15.00 per ADS.

The Company’s fiscal year ends December 31st.

Our American Depositary Shares are listed on the NASDAQ Global Select Market under the symbol “NCNA”.

The depositary for our American Depositary Shares is: Citibank, N.A. 388 Greenwich Street New York, New York, 10013

For questions about your ADSs please contact the depositary for our American Depositary Shares.

The transfer of your ADSs and replacement of your lost American Depositary Receipts, if any, among other matters, are governed by the Deposit Agreement, dated as of October 2, 2017, by and among us, the depositary of our American Depositary Shares and all holders and beneficial owners of American Depositary Shares issued thereunder, as amended from time to time, and by the American Depositary Receipt, if any, representing your ADSs. A copy of the form of such Deposit Agreement as of the date hereof (i) has been filed with the United States Securities and Exchange Commission (SEC) under cover of Pre-Effective Amendment No. 1 to Registration Statement on Form F-6 (Reg. No. 333-220392), (ii) may be retrieved from the SEC’s website (www.sec.gov), and (iii) is also available for inspection and copying at the public reference facilities maintained by the SEC in Washington, D.C. For questions about transfers of your ADSs or replacement of your lost American Depositary Receipts, please contact the depositary for our American Depositary Shares. If your ADSs are held in a brokerage account, you may also contact your broker with questions about transfers of your ADSs.

NuCana plc does not have a direct stock purchase plan.

The auditor for NuCana plc is Ernst & Young, LLP.

To find out more about NuCana plc, please visit our webpage at www.nucana.com.

NuCana plc’s press release archive can be viewed under the “Press Releases” section under the “Investors” tab and financial reports are available under the “Financial Information” section under the “Investors” tab located at our website www.nucana.com

NuCana plc SEC Filings can be found on www.sec.gov and are also available under the “Financial Information” section under the “Investors” tab located at our website www.nucana.com

For a list of the Executive Management team and the Board of Directors please visit the “Company” tab of our website.

For investor inquiries please contact: Christopher F. Brinzey Westwicke Partners EMAIL: chris.brinzey@westwicke.com PHONE: 339-970-2843